John Patitucci was born in Brooklyn, New York and began playing the electric bass at age ten. He began performing and composing at age 12, at age 15 began to play the acoustic bass, and then started the piano at age 16. He quickly moved from playing soul and rock to blues, jazz and classical music. His eclectic tastes caused him to explore all types of music as a player and a composer. John studied classical bass at San Francisco State University and Long Beach State University. In 1980, he continued his career in Los Angeles as a studio musician and a jazz artist.
As a studio musician, John has played on countless albums with artists such as B. B. King, Bonnie Raitt, Chick Corea, Wayne Shorter, Herbie Hancock, Michael Brecker, George Benson, Dizzy Gillespie, Was Not Was, Dave Grusin, Natalie Cole, Bon Jovi, Sting, Queen Latifah and Carly Simon. In 1986, John was voted by his peers in the studios as the National Academy of Recording Arts and Sciences MVP on Acoustic Bass.